Research Study Listings

Below is a list of active research studies that have been submitted by researchers to the NAA research portal. If you are a researcher interested in having your study listed below, please submit a request.

Molecular and Structural Imaging in Atypical Alzheimer's Disease

Participants are asked to come to the Mayo Clinic in Rochester, MN for 2-4 evaluations, each being one year apart. During those visits, participants are asked to complete an MRI, Amyloid PET scan, Tau PET scan, blood sample and Neuro exam.

Aphasia friendly listing description:

Patients with PPA (Logopenic variant) and PCA (Posterior Cortical Atrophy) are eligible to participate in this study.

City:
Rochester
State:
Minnesota
Start Date:
May 1, 2016
End Date:
April 30, 2026
Condition:
Primary Progressive Aphasia, Posterior Cortical Atrophy

Optimizing Targeted Interventions for Aphasia

Sixty-two patients who are one-year post-stroke and have aphasia due to stroke will be recruited. Participants will have four assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, one session immediately post-treatment, and one session at 3-month follow-up.

Aphasia friendly listing description:

You will complete an MRI and EEG along with speech-language assessment before treatment. Treatment will consist of 15 sessions in 3 weeks. During the treatment session, you will be fitted with a cap with electrodes for brain stimulation and complete one hour of naming treatment. Immediately after treatment, you will complete an EEG and language assessment and then again three months after treatment.

City:
Albuquerque
State:
New Mexico
Start Date:
April 30, 2021
End Date:
May 1, 2026
Condition:
Stroke

Activity, Health, and Burden in Caregivers

This research is studying the differences in life activities, participation levels, health-related behaviors, and mood between adults who identify as caregivers and adults who do not identify as caregivers. Participation will involve completing several short questionnaires to examine your life activities, participation levels, health-related behaviors, and mood. The survey should take about 30-45 minutes to complete.

Aphasia friendly listing description:

This study will examine life activities, participation, health-related behaviors, and mood for caregivers and non-caregiving controls. Participation will involve completing several short questionnaires to examine activities, participation, health-related behaviors, and mood. The survey should take about 30-45 minutes to complete.

City:
Albuquerque
State:
New Mexico
Start Date:
March 30, 2016
End Date:
December 31, 2025
Condition:

Electrophysiological and behavioral investigation of feedback-based learning in aphasia

The purpose of this research study is to better understand how aphasia due to stroke affects skills that support learning. We hope that a better understanding of learning will lead to improvements in treatments for aphasia in the future. This research study involves: • A learning task on the computer. You will see/hear made up words and objects, press buttons, and answer questions. We will record electrical activity in your brain using EEG. Recording EEG is noninvasive. You will wear a small mesh cap that contains small pads (also known as sensor electrodes) that will measure brain activity. • Completing standardized tests of language (speaking and listening) and cognition (thinking and remembering)

Aphasia friendly listing description:

What are we studying? We would like to understand how aphasia due to stroke affects skills that support learning. Understanding this may lead to improvements in aphasia treatment. What will you be asked to do? - Complete learning tasks on the computer. You will see and hear made up words and objects, press buttons, and answer questions - We will measure electrical activity in your brain using EEG while you learn. EEG is non-invasive. You will wear a mesh cap that contains small, damp pads that will measure brain activity. - Complete tests of language and cognition

City:
Boston
State:
Massachusetts
Start Date:
December 17, 2021
End Date:
April 14, 2023
Condition:
Stroke

Aphasia Research Study: Speaking Together

The goal of this study is to investigate how different ways of speaking can help people with aphasia speak more fluently. Participants will be asked to complete tests of language and musical rhythm, to repeat sentences, and to speak along with a recording. Testing takes place at the MGH Institute of Health Professions, in the Charlestown Navy Yard in Boston, MA.

Aphasia friendly listing description:

We want to see if different ways of speaking make it easier for you to get words out. We will ask you to do language tests. We will ask you to repeat sentences. We will ask you to speak along with recorded sentences. This study is in Boston.

City:
Boston
State:
Massachusetts
Start Date:
January 1, 2022
End Date:
February 28, 2024
Condition:
Stroke

Assessment of anomia: Improving efficiency and utility using item response theory

The purpose of this research study is to develop a standard scale for measuring the ability to name things in people who have aphasia. We will use this information to develop tests that are clinically useful and scientifically sound, and to develop a new computer adaptive test of naming. The ultimate goal of this study is to provide speech-language pathologists with better tools for evaluating the naming abilities of persons with aphasia.

Aphasia friendly listing description:

The purpose of this study is to develop a computerized test to assess word finding difficulties. To be included you must meet the following criteria: - Have aphasia (difficulty talking) after left side stroke - Speak English as your first language - No speech-language treatment during the study (2 weeks). Note: This is an in-person study. Must live near the Portland, Oregon metro area or be able to travel.

City:
Portland
State:
Oregon
Start Date:
April 6, 2021
End Date:
April 30, 2025
Condition:
Stroke, Aphasia

Translation and Clinical Implementation of a Test of Language and Short-term Memory in Aphasia

The study procedures consist of testing your speech, language, memory and organization. For the language tests you will be asked to compare the sounds and meanings of words, name and describe pictures, repeat words and sentences, and retell stories. For the memory tests, you will be asked to repeat a series of numbers and words, and identify numbers and words in the series. For the tests of your organizational abilities, you will be asked to recognize blocks and pictures, and organize letters and numbers. The purpose of this testing is to figure out how language and memory affects your ability to listen to, understand, remember and say words and sentences.

Aphasia friendly listing description:

After a stroke, many people have language and memory problems. We want to understand those problems better. It will help us make better aphasia tests. In this study, you will take tests of language and memory. Location - two options: Temple University in Philadelphia OR Zoom testing from your home.

City:
Philadelphia
State:
Pennsylvania
Start Date:
End Date:
Condition:
Stroke

fMRI Language and Cognition study

This study investigates the relationship between language and other cognitive abilities, as well as the reorganization of the language system after a stroke. The study involves a comprehensive assessment of language and cognitive abilities. This is done remotely over video-conferencing. The study also involves an in-person brain scanning session (MRI). We can provide a laptop to do the testing sessions at home if the participant does not have one. The sessions will be scheduled at times that work best for the participant. If you are interested, please contact us by email at brainrec@bu.edu or give us a call at 617-353-2706.

Aphasia friendly listing description:

In this study, researchers want to better understand language recovery in people with aphasia. We also examine how the brain reorganizes after a stroke. If you want to participate, you will do 8 to 10 behavioral testing sessions and 1 MRI scan. The testing sessions can be done on a computer at home. The MRI scan will be done at Boston University in Boston. We can provide a laptop to do the testing sessions at home if you do not have one. The sessions will be scheduled at times that work best for you. If you are interested, please contact us by email at brainrec@bu.edu or give us a call at 617-353-2706.

City:
Boston
State:
Massachusetts
Start Date:
September 1, 2020
End Date:
December 31, 2024
Condition:
Stroke

Improving aphasia outcomes through tDCS-mediated attention management

The Syracuse University Aphasia Lab is recruiting participants for a research study investigating brain stimulation and its effects on attention and language recovery. Transcranial Direct Current Stimulation (tDCS), a safe non-invasive type of electrical brain stimulation, will be used while participants receive speech and language therapy. Individuals who are 1) at least 18 years old, 2) have had a stroke, and 3) have experienced speech/language difficulties following their stroke are invited to take a brief, 5-minute screening questionnaire to determine eligibility for language and cognitive testing. The questionnaire is available by going to https://is.gd/aphasiastudy. If eligible based on screening questions, the participant will be scheduled for a 1-2 hour language and cognitive testing visit to determine eligibility for study treatment. If eligible for study treatment, participants will be asked to complete 1 pre-testing session, 10 language training sessions with tDCS, and 2 post-testing sessions, each of which will last between 1-2 hours. Eligible participants will be compensated up to $150 for completion of the study. Eligibility will be determined by the screening questionnaire and results of the initial language and cognitive testing. To learn more about the research, please contact Dr. Ellyn Riley at (315) 443-8688 or visit aphasialab.syr.edu. The Aphasia Lab is located on the Syracuse University South Campus at 621 Skytop Road in Syracuse, NY.

Aphasia friendly listing description:

The Syracuse University Aphasia Lab is currently recruiting adults who experience language difficulties following a stroke. The treatment used in this study will combine an electrical brain stimulation technique, called tDCS, with attention and language behavioral therapy. To learn more, please call Dr. Ellyn Riley at (315) 443-8688 or visit our website: aphasialab.syr.edu.

City:
Syracuse
State:
New York
Start Date:
September 23, 2020
End Date:
August 31, 2023
Condition:
Stroke

The Ohio State University - Aphasia Lab Study

The Ohio State University’s Aphasia Laboratory is currently seeking participants for an NIHfunded project involving a free speech therapy for adults with language impairments after a stroke. Results from this work may assist families and patients in making informed stroke rehabilitation decisions, based on unique characteristics, such as genetics, cognitive skills, and brain structure after stroke. This study is mostly virtual and we can loan participants a laptop computer, and/or internet access if needed. Most in-person sessions can be held either in our lab (OSU’s campus) or at the participant’s home. The required MRI must occur at our elected facility in Columbus, OH. Participants will be paid $20 per session. Participants must fit the following criteria: • Between the ages of 18 and 85 • Native English speaker • Have had a left hemisphere stroke • Able to have an MRI If you or someone you know may be interested in getting involved, please call (614) 247-1982 or email aphasialab@osu.edu. For more information, feel free to visit our website, u.osu.edu/aphasialab/.

Aphasia friendly listing description:

Looking to join a research study for person's with aphasia? We are looking for adults with language impairments after a stroke. The results from this study will help better understand what therapy techniques work best based on factors such as genetics, every-day decision making skills, and brain structure.

City:
Columbus
State:
Ohio
Start Date:
August 21, 2019
End Date:
August 30, 2025
Condition:
Stroke

How Stroke Affects Activities of Daily Living

Online or in-person behavior testing for two hours; for interested participants it can also involve a 1.5-hour MRI session. The goal of the study is to understand how the brain systems that support seeing, speaking and understanding work together.

Aphasia friendly listing description:

We want to understand how stroke affects everyday abilities like recognizing familiar objects and people, speaking one's thoughts and grasping and using objects.

City:
Pittsburgh
State:
Pennsylvania
Start Date:
October 10, 2022
End Date:
October 10, 2024
Condition:
Stroke

Diagnostic Markers of Language Impairment in Spanish-English speakers

Our goal is to improve services for Spanish-English speaking adults who need to see a Speech-Language Pathologist due to brain injury. We are developing language assessments to more accurately diagnose conditions such as aphasia and dementia. We aim to improve access to speech-language therapy services for bilingual speakers and reduce health disparities with our research. For some background information, we are recruiting adult speakers who are 30-70 years old and are: monolingual English speakers, or highly proficient Spanish-English bilingual speakers, or Spanish-English bilingual speakers with a diagnosis of aphasia, who were highly proficient in both languages prior to their brain injury. All participation will be completed online over the computer. For monolingual English speakers, the procedures involve a 15-minute phone screen, and 2 hours of testing, and they will be reimbursed $50 at the completion of the study. For bilingual Spanish-English speakers, the procedures involve a 25 minute phone screen and 5 hours of testing (over two to three sessions). They will be reimbursed $100 at the completion of the study.

Aphasia friendly listing description:

We are developing aphasia tests for bilingual Spanish-English speakers. You are eligible if you are a Spanish-English speaker with aphasia. You will participate online over a computer. Participation invovles 25 minute phone screen and two to three sessions of testing (about 5 hours total). You will be paid $100 at the completion of the study.

City:
College Park
State:
Maryland
Start Date:
July 1, 2022
End Date:
June 30, 2023
Condition:
Stroke

Development of The Brief Cope for Aphasia

Recruiting participants with aphasia and their caregivers for an online research study. The purpose of the study is to develop a coping questionnaire for patients with post-stroke aphasia. Relatively little is known about stress and coping among patients with post-stroke aphasia. Currently there exists no coping questionnaires developed specifically for people with aphasia. The current study aims to develop an aphasia coping questionnaire.

Aphasia friendly listing description:

We want to develop a coping questionnaire for people with aphasia to learn more about stress and coping.

City:
Atlanta
State:
Georgia
Start Date:
December 2, 2021
End Date:
August 31, 2025
Condition:
Stroke

Modulating stimuli intensity to improve clinical outcomes in aphasia treatment (VIRTUAL)

The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia following a stroke. Using a computer-based speech and language therapy program, participants will practice conversational scripts that are either short or long. Participants will practice for either 2 weeks (5 days a week) or for 5 weeks (2 days a week).

Aphasia friendly listing description:

• Conversation practice on the computer with a “virtual therapist” • We will loan you all equipment needed for the study • Participation in the study lasts either 11 weeks or 14 weeks • You will receive 10 treatment sessions. Treatment lasts either 2 weeks or 5 weeks: o 2-week schedule: 1 hour/day, 5 days/week o 5-week schedule: 1 hour/day, 2 days/week • All visits online (Zoom) OR in-person with Shirley Ryan AbilityLab research staff: o Evaluations (4 times, 1-2 days each) o Training (1-2 days)

City:
Chicago
State:
Illinois
Start Date:
September 21, 2020
End Date:
June 30, 2024
Condition:
Stroke

Phase III Development of a Valid, Reliable, Clinically Feasible Measure of Transactional Success in Aphasic Conversation

The purpose of this study is to validate a measure of transactional success in semi-structured conversation in aphasia. Participants will attend four 1-hour sessions over a period of approximately two weeks, administered entirely over Zoom. In the first two sessions, we will acquire traditional measures of language and cognition, including typical discourse elicited from picture descriptions. In the second two sessions, participants will view four short video clips. After each one, they will describe what they saw/heard to the administrator, then engage in a six-minute conversation with a familiar or unfamiliar conversation partner, after which the partner will retell the story.

Aphasia friendly listing description:

We know that people with aphasia communicate better than they talk, but we do not have good tests to measure how well they communicate in conversation with others. The purpose of this study is to demonstrate that the test we are developing is correctly measuring what we intend to measure and that it consistently does a good job of measuring success in conversation. Participants will attend four 1-hour sessions over a period of approximately two weeks. All test sessions will be administered over Zoom. In the first two sessions, we will collect the usual measures of language and cognition, including descriptions of pictures. In the second two sessions, participants will view four short video clips, each lasting about 2.5 minutes. After each video, they will describe what they saw and heard to the SLP. After that, they will have a six-minute conversation with a familiar or unfamiliar conversation partner about what they saw and heard. Finally, the conversation partner will retell the story.

City:
Amherst
State:
Massachsetts
Start Date:
July 1, 2022
End Date:
June 30, 2024
Condition:
Stroke

Examining Telehealth Administration of Aphasia and Cognitive Screening Tests for Individuals with Post-Stroke Aphasia: A Validity and Feasibility Study

Aphasia, most commonly caused by a stroke, is a language disorder which hinders the ability to communicate effectively. It is an impairment of language, typically affecting two or more of the following: the production or comprehension of spoken, written or nonverbal aspects of communication. This study will specifically involve individuals who have been diagnosed with aphasia following their stroke. Early identification of patients with stroke-induced aphasia is essential because it is a significant disability affecting daily life and is linked to multiple co-existing sensory, motor, cognitive, and functional problems after stroke. Therefore, this study will examine a brief screening protocol that can be administered via telehealth practices which includes the assessment of both language and cognition so that individuals with post-stroke aphasia can be quickly and conveniently diagnosed. This will be done via Zoom Video Communications Inc. as the videoconference platform where individuals will be able to stay in their preferred locations. During the telehealth session, participants will be administered two screening tests, regarding both language and cognitive abilities. Along with this, corresponding self-reported measures will be given to participants to report on their subjective language/cognitive abilities.

Aphasia friendly listing description:

We would like to know if our assessment can be done online. Participants will attend a session via Zoom that will include brief language and cognitive tests. They will also be able to answer questions related to their experience of this online session.

City:
London, ON
State:
Michigan
Start Date:
January 5, 2022
End Date:
January 2, 2023
Condition:
Stroke

Speech and language processing in people with aphasia

The research involves four sessions that are two- to three-hours long where you do the following: complete tasks assessing speech and language processing; listen to an audiobook and a clip from a podcast while electroencephalography (EEG) data are collected.

Aphasia friendly listing description:

You will do some tests like you would with a speech therapist. You will also listen to a story while we record brain activity using EEG.

City:
Houston
State:
Texas
Start Date:
October 7, 2022
End Date:
December 31, 2024
Condition:
Stroke

Phonological Distance in Aphasia

We want to know how people with aphasia process similar sounding words (e.g., CAT and BAT). Participants will complete language tasks, like listening to words in noise and indicating if two words sound similar. Participants will also complete a speech and language evaluation.

Aphasia friendly listing description:

We want to know how people with aphasia process similar sounding words (e.g., CAT and BAT). Participants will complete language tasks, like listening to words in noise and indicating if two words sound similar. Participants will also complete a speech and language evaluation.

City:
Buffalo
State:
New York
Start Date:
December 1, 2021
End Date:
June 30, 2023
Condition:
Stroke, Aphasia

Aphasia Therapy Outcomes

We are looking for volunteers who are within driving distance to Hershey, PA. We want to understand how the brain changes in response to naming therapy. Volunteers will complete a 10-week intensive naming therapy. Each session will be 2 hours and there are 2 sessions each a week. Volunteers will also come to Hershey Medical Center for a total of 4 MRI scans. Two MRI scans happen before treatment and 2 scans happen after treatment. A language assessment will also be given before and after naming therapy. In-person visits for MRI scans are required, and compensation for travel time is provided up to two hours each way. Naming therapy and assessment sessions can be conducted virtually via Zoom.

Aphasia friendly listing description:

We are looking for volunteers who are within driving distance to Hershey, PA. We want to understand how the brain changes in response to naming therapy. Volunteers will complete a 10-week intensive naming therapy. Each session will be 2 hours and there are 2 sessions each a week. Volunteers will also come to Hershey Medical Center for a total of 4 MRI scans. Two MRI scans happen before treatment and 2 scans happen after treatment. A language assessment will also be given before and after naming therapy. In-person visits for MRI scans are required, and compensation for travel time is provided up to two hours each way. Naming therapy and assessment sessions can be conducted virtually via Zoom.

City:
Hershey
State:
Pennsylvania
Start Date:
June 1, 2018
End Date:
May 1, 2023
Condition:
Stroke

Exploring the Impact of Caregiving on Friendships of Caregivers of Stroke Survivors with Aphasia

This project aims to better understand how caregiving impacts friendships of aphasia care partners over time, including the time before caregiving and during the acute and chronic stages of caregiving for their loved one with aphasia. This is a remote study and can be completed on a computer and smartphone. The first part of the study involves completing a survey about caregiving and friendship on the computer. The second, optional, part of the study involves using a free smartphone application for 14 days to take daily surveys that ask about what you are doing and how you are feeling.

Aphasia friendly listing description:

We want to know how a care partner's friendships might change over time and they feel about their friendships.

City:
Tallahassee
State:
Florida
Start Date:
July 1, 2022
End Date:
March 31, 2023
Condition:
Stroke

Assessment of anomia: Improving efficiency and utility using item response theory

The purpose of this research study is to develop a standard scale for measuring the ability to name things in people who have aphasia. We will use this information to develop tests that are clinically useful and scientifically sound, and to develop a new computer adaptive test of naming. The ultimate goal of this study is to provide speech-language pathologists with better tools for evaluating the naming abilities of persons with aphasia.

Aphasia friendly listing description:

City:
Pittsburgh
State:
PA
Start Date:
April 6, 2021
End Date:
April 30, 2025
Condition:
Aphasia

Semantic Feature Analysis Treatment for Aphasia

This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.

Aphasia friendly listing description:

City:
Pittsburgh
State:
PA
Start Date:
February 24, 2020
End Date:
April 30, 2024
Condition:
Aphasia

Electrophysiological and Behavioral Investigation of Feedback-based Learning in Aphasia

We would like to understand how aphasia due to stroke affects skills that support learning. Understanding this may lead to improvements in aphasia treatment in the future. Participants will come to our lab at MGH Institute of Health Professions in the Charlestown Navy Yard (Boston). The study will involve: - Completing learning tasks on the computer. You will see and hear made up words and objects, press buttons, and answer questions - Measuring electrical activity in your brain using EEG while you learn - Completing tests of language and cognition

Aphasia friendly listing description:

City:
Boston
State:
Massachusetts
Start Date:
April 15, 2021
End Date:
April 14, 2022
Condition:
Stroke

Does Treating Working Memory Improve Spoken Naming Abilities in Individuals with Aphasia?

The purpose of the study is to investigate whether a working memory-naming treatment approach will help spoken naming abilities. Participation in this study involves testing the individual’s cognitive-language abilities prior to and after treatment. The treatment approach involves naming pictures, describing the pictures, repeating words, answering questions, and remembering words.

Aphasia friendly listing description:

City:
Ypsilanti
State:
Michigan
Start Date:
March 1, 2022
End Date:
Condition:
Stroke

Neural and Cognitive Bases of Language Processing

The purpose of the study is to answer questions about normal and impaired language processing and their underlying neural and cognitive mechanisms. Specifically, how persons with aphasia understand & produce words and sentences using different experiments. * remote and in-person testing is available *participants will be asked to produce/listen to sentences. At times when looking at a computer screen which tracks eye movements. * sessions are approximately 2 hours in length

Aphasia friendly listing description:

City:
West Lafayette
State:
Indiana
Start Date:
June 1, 2022
End Date:
June 11, 2025
Condition:
Stroke

Inner speech as a predictor of improved naming after speech therapy in persons with aphasia

The purpose of this study is to understand “inner speech” (knowing the name for something in your head) predicts how you name objects aloud after speech therapy. This study will require ~22 hours across five weeks. You will be asked to name some pictures and answer questions about those pictures. You will then participate in three weeks of speech-language therapy to improve your picture naming.

Aphasia friendly listing description:

City:
Bloomington
State:
Indiana
Start Date:
January 1, 2022
End Date:
January 1, 2023
Condition:
Stroke