The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.

This trial is investigating the use of non-invasive brain stimulation combined with speech therapy as an effective treatment approach for people with post- stroke aphasia.

- diagnosis of aphasia: Broca's or mixed (based on the assessment of a Speech Language Pathologist) - presence of a focus of injury in the left hemisphere (within one hemisphere only) as a result of the first ischemic or hemorrhagic stroke (based on CT/MRI examination); - chronic stage of the disease - time since the stroke occurred over 6 months. - ability to achieve an accuracy in the Naming Task of 10-60%. - 18-80 years - right-handedness before the stroke. - ability to give informed written consent. - fluency in English. Exclusion Criteria: - severe cognitive, auditory or visual impairment that would preclude cognitive and language testing - inability to follow a two-step command. - presence of metal implants in the skull. - presence of major untreated or unstable psychiatric disease. - history of epilepsy or seizures. - ongoing medication that increases the risk of epileptic seizures. - presence in the body of cardiac stimulators or pacemaker. - history of speech, language, hearing, or intellectual disability during childhood. - pregnancy (based on declarations)

Miguel Escalon

miguel.escalon@mountsinai.org

Stroke

Treatment

Non-invasive brain stimulation paired with naming treatment

Participants will attend 4 appointments (~1 hour each) over 4 weeks to complete baseline assessments and fMRI to determine eligibility to participate in treatment protocol. treatment protocol is 10 sessions over two consecutive weeks (daily Monday- Friday) for approximately 1 hour each. follow up sessions are conducted immediately following the last treatment session, at 6 weeks, and at 12 weeks.

March 20, 2025

$150 visa gift card

2101577