Optimizing Targeted Interventions for Aphasia

Study Description:
Sixty-two patients who are one-year post-stroke and have aphasia due to stroke will be recruited. Participants will have four assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, one session immediately post-treatment, and one session at 3-month follow-up.
Aphasia Friendly Study Description:
You will complete an MRI and EEG along with speech-language assessment before treatment. Treatment will consist of 15 sessions in 3 weeks. During the treatment session, you will be fitted with a cap with electrodes for brain stimulation and complete one hour of naming treatment. Immediately after treatment, you will complete an EEG and language assessment and then again three months after treatment.
Inclusion / Exclusion Criteria:
Aged 25-85 Must be greater than one year post-stroke Must have a diagnosis of aphasia based on impaired performance on the Western Aphasia Battery-Revised, Boston Naming Test or during discourse production Must be left-hemisphere dominant as demonstrated by aphasia onset after left-hemisphere damage Must be stimulable for naming Exclusion Criteria: Comorbid neurological disease. damage to the anterior right hemisphere Significantificant mood disorder. Substance/alcohol dependence or abuse within the past year Presence of any implanted electrical device or contraindications to tDCS or MRI Recent medical instability (within four weeks) Pregnancy
Principal Investigator:
Jessica Richardson
Contact Email:
Observational or Treatment:
Type of Treatment:
Naming Treatment (Semantic Feature Analysis and Phonological Component Analysis)
Duration of Study:
Participants completed 2 pre-treatment assessment sessions, 15 consecutive treatment sessions (weekdays only, 3 weeks), a single post-treatment assessment, and a single 3-month follow-up assessment. The duration for study participation is approximately 4 months,
Study Start Date:
April 30, 2021
Study End Date:
May 1, 2026
Costs or Reimbursement:
Participants will receive $40 dollars for each assessment session (4 sessions), and $75 per week of treatment (3 weeks)
IRB Approval #
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