Semantic Feature Analysis Treatment for Aphasia

Study Description:
This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.
Aphasia Friendly Study Description:
Inclusion / Exclusion Criteria:
Inclusion Criteria: 6 months post-onset of aphasia due to unilateral left-hemisphere (LH) stroke Independent in activities of daily living (ADLs) necessary to live in community-based housing or available caregiver to assist with ADLs Medically stable and able to tolerate intensive treatment schedule (e.g. no uncontrolled seizures, difficulty breathing, frequent migraines) English as a first language No participation in any other speech-language treatment during this study, including follow-up period Sufficient auditory comprehension abilities demonstrated during screening Sufficient naming impairment exhibited during screening Exclusion Criteria: Right Hemisphere stroke Neurological disease other than stroke Significant psychiatric disorder Severe motor speech disorder Active substance dependence
Principal Investigator:
William Hula
Contact Email:
Observational or Treatment:
Type of Treatment:
Word-finding treatment
Duration of Study:
4-5 weeks treatment plus 2 days follow-up
Study Start Date:
February 24, 2020
Study End Date:
April 30, 2024
Costs or Reimbursement:
Please contact us for further details.
IRB Approval #
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